Endocrine Abstracts

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

Introduction: Recently, a single nucleotide polymorphism (SNP) in the FSH (FSH)-β gene (FSHB −211G>T, rs10835638) that leads to reduced mRNA transcription was associated with serum FSH levels in an Estonian cohort of young men (Grigorova et al., Hum Reprod 2008). Further investigations showed an increased frequency of the T-allele in patients with oligozoospermia compared to men with normozoospermia (Grigorova et al., JCEM 2010). Another Bal...

In rats, we have previously demonstrated that consumption of low-carbohydrate/high-fat diets (LC–HFD) led to significant reductions in circulating IGF1. We further observed that rats fed an extreme, ketogenic, but comparably low protein LC–HFD (LC–HF-2) showed loss of bodyweight, which was mainly due to loss of lean body mass (LBM). Consumption of a moderate protein LC–HF diet (LC–HF-1) did not affect LBM acquisition compared to controls. We now invest...

Introduction: In case of inoperable disease or tumor recurrence, therapy with mitotane (MIT), sometimes in combination with doxorubicin (DOX), etoposide (ETO), cisplatin (CIS) or streptozocin (STREP), is frequently applied in patients with adrenocortical carcinoma (ACC). The multidrug resistance pump MDR1 is responsible for resistance of tumor cells to cytostatic drugs. The activity of MDR1 is inhibited by the calcium-channel blocker verapamil. There are equivocal data in the ...

Aims/hypothesis: Several data have shown the association between diabetes type 2 (DM2) and transcription factor 7-like 2 (TCF7L2) gene polymorphisms, in several and different ethnical populations. Although the pathophysiology is not completely clear, it seems that beta and alpha cell functions are abnormal. Up to these days there is no clinical data showing association between TCF7L2 gene polymorphism allele rs7903146 T and beta cell insulin and C-peptide contents in DM2 patie...

Conditions such as pre-eclampsia and intrauterine growth restriction highlight the importance of normal placental cell turnover for successful pregnancy outcome. In these conditions abnormal levels of proliferation and increased apoptosis have been reported; aberrations in components of the IGF axis have also been observed. IGFs regulate proliferation and survival in other cellular systems but their ability to influence human placental cell function remains to be established.<...

Introduction: Elastography is a new dynamic technique that uses ultrasonography for the assessment of tissue stiffness. The principle of ultrasound-elastography is that compression of the examined tissue induces a smaller strain in hard tissues than in soft ones. Until now elastography has been applied to study the hardness and elasticity of thyroid nodules, aiming to differentiate malignant from benign ones.Aim: We decided to study if ultrasound elastog...

Vitamin D (VitD) was shown to affect biology of vascular wall by regulating cell proliferation. However, its effects on vascular extracellular matrix (ECM) remain largely unaddressed. We investigated effects of VitD (calcitriol) on composition of ECM deposed by cultured endothelial cells (HAEC) and smooth muscle cells (HASMC) isolated from human aorta, and compared them to effects of ascorbate (VitC). Cellular monolayers were treated with or without vitamins for 72 h, then ECM...

Bisphenol A (BPA) is an endocrine disruptor (ED) used as plasticiser present in plastic products of daily use. The leakage of BPA monomer into food, drinks represents the ubiquitous exposure to the general population. BPA stimulatory effect on breast cancer cells growth in vitro and increased incidence of hormone dependent malignancies suspected BPA from carcinogenic effect.The aim of this study was to investigate the effects of BPA alone and in t...

Metabolic pathologies mainly originate from dysfunctions of the white adipose tissue (AT). Functional differences in AT and their impact on metabolism seem associated with the fat depot regional distribution, in particular the subcutaneous (SAT) and visceral (VAT) pads. Human adult adipose stem cell (ASC) populations have recently been characterized from SAT and VAT. In this study, using human ASC cultures obtained from paired biopsies of abdominal SAT, S-ASC, and VAT, V-ASC, ...